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The gravity of the current Ebola epidemic is such that for the first time in history an international consortium has been assembled in order to accelerate the development and deployment of potential vaccines. The Jenner Institute in Oxford will run the first phase I trial of a vaccine targeted at the Zaire strain of Ebola virus that is causing the current outbreak. The main purpose of this first-in-humans trial in the UK is to establish a detailed safety profile of the vaccine and assess the type of immune responses it induces before it could be considered for widespread use. A further goal is to identify the most suitable dose of the vaccine. The vaccine is being co-developed with GlaxoSmithKline and the National Institutes of Health who are running parallel human phase I trials in the US.



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