Inovio Pharmaceuticals (NASDAQ: INO) and Oncobiologics (NYSE:ONS) are both small-cap medical companies, but which is the superior business? We will contrast the two companies based on the strength of their dividends, valuation, profitability, institutional ownership, earnings, risk and analyst recommendations.


This table compares Inovio Pharmaceuticals and Oncobiologics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Inovio Pharmaceuticals -153.46% -63.67% -46.77%
Oncobiologics -1,757.25% N/A -123.55%

Institutional & Insider Ownership

24.8% of Inovio Pharmaceuticals shares are owned by institutional investors. 10.6% of Inovio Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company is poised for long-term growth.

Valuation and Earnings

This table compares Inovio Pharmaceuticals and Oncobiologics’ gross revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio EBITDA Earnings Per Share Price/Earnings Ratio
Inovio Pharmaceuticals $51.84 million 10.39 -$70.60 million ($1.08) -5.53
Oncobiologics $1.40 million 29.08 -$41.02 million N/A N/A

Oncobiologics has higher revenue, but lower earnings than Inovio Pharmaceuticals.

Analyst Ratings

This is a summary of recent recommendations and price targets for Inovio Pharmaceuticals and Oncobiologics, as provided by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Inovio Pharmaceuticals 0 2 8 0 2.80
Oncobiologics 0 1 1 0 2.50

Inovio Pharmaceuticals currently has a consensus target price of $20.90, suggesting a potential upside of 250.08%. Oncobiologics has a consensus target price of $9.00, suggesting a potential upside of 445.45%. Given Oncobiologics’ higher possible upside, analysts clearly believe Oncobiologics is more favorable than Inovio Pharmaceuticals.


Inovio Pharmaceuticals beats Oncobiologics on 7 of the 11 factors compared between the two stocks.

Inovio Pharmaceuticals Company Profile

Inovio Pharmaceuticals, Inc. (Inovio) is a clinical-stage pharmaceutical company, which is involved in developing deoxyribonucleic acid (DNA) immunotherapies and vaccines focused on treating and preventing cancers and infectious diseases. The Company’s DNA-based immunotherapies, in combination with its electroporation delivery devices, generates immune responses, in particular T cells, in the body to fight target diseases. It has completed, current or planned clinical programs of its SynCon immunotherapies for human papillomavirus (HPV)-caused pre-cancers and cancers, influenza, prostate cancer, breast/lung/pancreatic cancer, hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV), Ebola, Middle East Respiratory Syndrome (MERS) and Zika virus. With its immunotherapy platform, as well as with its CELLECTRA electroporation delivery technology, it has a pipeline of pre-clinical and clinical stage products that have generated in vivo immune responses.

Oncobiologics Company Profile

Oncobiologics, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on identifying, developing, manufacturing and commercializing biosimilar therapeutics. It is focused on monoclonal antibodies (mAbs) in the disease areas of immunology and oncology. The Company offers BioSymphony Platform. The Company has identified approximately eight biosimilar product candidates, of which two product candidates are ONS-3010 and ONS-1045. ONS-3010 is an adalimumab (Humira) biosimilar. The Company has initiated Phase III preparatory activities for ONS-3010. Its second product candidate, ONS-1045, is a bevacizumab (Avastin) biosimilar. The Company’s other preclinical product candidate, ONS-1050, a trastuzumab (Herceptin) biosimilar, interferes with the human epidermal growth factor receptor 2 (HER2). ONS-4010 is a biosimilar to denosumab (Prolia/Xgeva), which is a human mAb. Its other biosimilar product, ONS-1055, is a biosimilar to cetuximab (Erbitux).

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