Curis (NASDAQ: CRIS) and Kala Pharmaceuticals (NASDAQ:KALA) are both small-cap medical companies, but which is the better stock? We will compare the two companies based on the strength of their risk, dividends, institutional ownership, earnings, analyst recommendations, profitability and valuation.

Profitability

This table compares Curis and Kala Pharmaceuticals’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Curis -836.18% -236.43% -88.44%
Kala Pharmaceuticals N/A N/A N/A

Institutional & Insider Ownership

44.7% of Curis shares are owned by institutional investors. 4.1% of Curis shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.

Analyst Ratings

This is a summary of current ratings for Curis and Kala Pharmaceuticals, as reported by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Curis 0 0 3 0 3.00
Kala Pharmaceuticals 0 0 5 0 3.00

Curis currently has a consensus price target of $6.50, indicating a potential upside of 303.73%. Kala Pharmaceuticals has a consensus price target of $36.80, indicating a potential upside of 60.63%. Given Curis’ higher probable upside, research analysts plainly believe Curis is more favorable than Kala Pharmaceuticals.

Earnings & Valuation

This table compares Curis and Kala Pharmaceuticals’ revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio EBITDA Earnings Per Share Price/Earnings Ratio
Curis $8.31 million 27.88 -$48.51 million ($0.50) -3.22
Kala Pharmaceuticals N/A N/A N/A N/A N/A

Kala Pharmaceuticals has higher revenue, but lower earnings than Curis.

About Curis

Curis, Inc. is a biotechnology company seeking to develop and commercialize drug candidates for the treatment of cancers. The Company’s drug candidate is CUDC-907, an orally-available, small molecule inhibitor of histone deacetylase (HDAC) and phosphatidylinositol-3-kinase (PI3K) enzymes. CUDC-907 is an oral, dual inhibitor of Class I and II HDAC, as well as Class I PI3K enzymes. CA-170 is an oral small molecule drug candidate that is designed to selectively target programmed death ligand-1 (PDL1) and V-domain Ig suppressor of T-cell activation (VISTA) immune checkpoint proteins, both of which independently function as negative regulators of immune activation. CA-4948 is an oral small molecule drug candidate that is designed to inhibit the Interleukin-1 receptor-associated kinase 4 (IRAK4) kinase, which is a transducer of toll-like receptor or certain interleukin receptor signaling pathways.

About Kala Pharmaceuticals

Kala Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development and commercialization of therapeutics through its nanoparticle-based Mucus Penetrating Particles, or MPP, technology. The Company’s initial focus is on the treatment of eye diseases. The Company’s product candidate includes KPI-121 1%, KPI-121 0.25% and MPP rTKI Program. The Company has completed two Phase III clinical trials for KPI-121 1% . The KPI-121 0.25% is the Company’s product candidate for temporary relief of signs and symptoms of dry eye disease. KPI-121 1% is the twice-a-day product candidate for treatment of post-operative inflammation and pain following ocular surgery. MPP rTKI Program is therapies for retinal diseases that should be injected directly into the patient’s eye, often at monthly intervals.

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