Advaxis (NASDAQ: ADXS) and Zynerba Pharmaceuticals (NASDAQ:ZYNE) are both small-cap medical companies, but which is the superior investment? We will compare the two companies based on the strength of their analyst recommendations, profitability, risk, valuation, earnings, institutional ownership and dividends.

Institutional & Insider Ownership

48.1% of Advaxis shares are owned by institutional investors. Comparatively, 34.3% of Zynerba Pharmaceuticals shares are owned by institutional investors. 7.2% of Advaxis shares are owned by insiders. Comparatively, 10.0% of Zynerba Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Risk & Volatility

Advaxis has a beta of 2.17, suggesting that its share price is 117% more volatile than the S&P 500. Comparatively, Zynerba Pharmaceuticals has a beta of 5.46, suggesting that its share price is 446% more volatile than the S&P 500.

Analyst Recommendations

This is a summary of current ratings and recommmendations for Advaxis and Zynerba Pharmaceuticals, as reported by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Advaxis 0 0 2 0 3.00
Zynerba Pharmaceuticals 0 5 4 0 2.44

Advaxis presently has a consensus price target of $21.00, suggesting a potential upside of 360.53%. Zynerba Pharmaceuticals has a consensus price target of $14.63, suggesting a potential upside of 45.96%. Given Advaxis’ stronger consensus rating and higher possible upside, equities research analysts clearly believe Advaxis is more favorable than Zynerba Pharmaceuticals.

Profitability

This table compares Advaxis and Zynerba Pharmaceuticals’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Advaxis -655.66% -93.54% -64.49%
Zynerba Pharmaceuticals N/A -54.35% -48.11%

Earnings & Valuation

This table compares Advaxis and Zynerba Pharmaceuticals’ top-line revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio EBITDA Earnings Per Share Price/Earnings Ratio
Advaxis $14.01 million 13.37 -$93.95 million ($2.29) -1.99
Zynerba Pharmaceuticals N/A N/A -$28.66 million ($2.62) -3.82

Zynerba Pharmaceuticals has higher revenue, but lower earnings than Advaxis. Zynerba Pharmaceuticals is trading at a lower price-to-earnings ratio than Advaxis, indicating that it is currently the more affordable of the two stocks.

Summary

Zynerba Pharmaceuticals beats Advaxis on 7 of the 12 factors compared between the two stocks.

About Advaxis

Advaxis, Inc. is a clinical-stage biotechnology company focused on the discovery, development and commercialization of Listeria monocytogenes (Lm)-Listeriolysin O (LLO) cancer immunotherapies. These immunotherapies are based on a platform technology that utilizes live attenuated Lm bioengineered to secrete antigen/adjuvant fusion proteins. These Lm-LLO strains integrate multiple functions into a single immunotherapy as they access and direct antigen presenting cells to stimulate anti-tumor T-cell immunity, stimulate and activate the immune system with the equivalent of multiple adjuvants, and simultaneously reduce tumor protection in the tumor microenvironment to enable the T-cells to eliminate tumors. Axalimogene filolisbac is its lead Lm-LLO immunotherapy product candidate for the treatment of Human Papilloma Virus-associated cancers. ADXS-PSA is its Lm-LLO immunotherapy product candidate that targets the Prostate Specific Antigen (PSA) associated with prostate cancer.

About Zynerba Pharmaceuticals

Zynerba Pharmaceuticals, Inc. is a specialty pharmaceutical company. The Company is engaged in developing and commercializing transdermal synthetic cannabinoid treatments for patients with high unmet needs. Its development pipeline includes two product candidates: ZYN002 and ZYN001. ZYN002 is a synthetic cannabidiol (CBD), which is a non-psychoactive cannabinoid, formulated as a patent-protected permeation-enhanced gel for transdermal delivery through the skin and into the circulatory system. ZYN002 is in Phase II clinical development in patients with refractory epilepsy, in patients with osteoarthritis of the knee, as well as in patients with Fragile X syndrome. ZYN001 is a pro-drug of tetrahydrocannabinol (THC) that enables transdermal delivery through the skin and into the circulatory system through a patch. ZYN001 is targeting two pain indications, fibromyalgia and peripheral neuropathic pain.

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