Syros Pharmaceuticals (NASDAQ: SYRS) and Cardiome Pharma Corporation (NASDAQ:CRME) are both small-cap medical companies, but which is the better stock? We will compare the two companies based on the strength of their earnings, risk, analyst recommendations, profitability, institutional ownership, dividends and valuation.


This table compares Syros Pharmaceuticals and Cardiome Pharma Corporation’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Syros Pharmaceuticals N/A -60.15% -54.25%
Cardiome Pharma Corporation -110.95% -78.51% -38.30%

Analyst Ratings

This is a breakdown of recent ratings and price targets for Syros Pharmaceuticals and Cardiome Pharma Corporation, as provided by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Syros Pharmaceuticals 0 0 6 0 3.00
Cardiome Pharma Corporation 0 0 4 0 3.00

Syros Pharmaceuticals presently has a consensus target price of $26.37, indicating a potential upside of 56.49%. Cardiome Pharma Corporation has a consensus target price of $7.58, indicating a potential upside of 283.00%. Given Cardiome Pharma Corporation’s higher probable upside, analysts plainly believe Cardiome Pharma Corporation is more favorable than Syros Pharmaceuticals.

Institutional and Insider Ownership

59.6% of Syros Pharmaceuticals shares are held by institutional investors. Comparatively, 55.2% of Cardiome Pharma Corporation shares are held by institutional investors. 33.6% of Syros Pharmaceuticals shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Risk & Volatility

Syros Pharmaceuticals has a beta of -3.72, meaning that its share price is 472% less volatile than the S&P 500. Comparatively, Cardiome Pharma Corporation has a beta of 1.09, meaning that its share price is 9% more volatile than the S&P 500.

Valuation & Earnings

This table compares Syros Pharmaceuticals and Cardiome Pharma Corporation’s top-line revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio EBITDA Earnings Per Share Price/Earnings Ratio
Syros Pharmaceuticals $1.42 million 311.61 -$48.99 million ($2.13) -7.91
Cardiome Pharma Corporation $23.21 million 2.88 -$17.41 million ($0.83) -2.39

Cardiome Pharma Corporation has higher revenue and earnings than Syros Pharmaceuticals. Syros Pharmaceuticals is trading at a lower price-to-earnings ratio than Cardiome Pharma Corporation, indicating that it is currently the more affordable of the two stocks.

Syros Pharmaceuticals Company Profile

Syros Pharmaceuticals, Inc. is a biopharmaceutical company. The Company offers a gene control platform designed to analyze the unexploited region of deoxyribonucleic acid (DNA) in human disease tissue to identify and drug targets linked to genomically defined patient populations. The Company is focused on developing treatments for cancer and immune-mediated diseases and is building a pipeline of gene control medicines. The Company’s drug programs include SY-1425 (retinoic acid receptor alpha (RARa) agonist) and SY-1365 (cyclin-dependent kinase 7 (CDK7) inhibitor). SY-1425 (tamibarotene) is an oral, potent and selective agonist, or activator, of the transcription factor RARa. SY-1365 is a small molecule inhibitor of the transcriptional kinase known as CDK7. The Company is using its platform to analyze gene expression programs across additional cancers, inflammatory diseases and other diseases to identify optimal points of therapeutic intervention in specific subsets of patients.

Cardiome Pharma Corporation Company Profile

Cardiome Pharma Corp. (Cardiome) is a specialty pharmaceutical company. The Company is engaged in the development and commercialization of cardiovascular therapies for heart disease. The Company’s segments are Europe and Rest of World. Cardiome has two marketed, in-hospital, cardiology products, which include BRINAVESS (vernakalant IV), approved in Europe and other territories for the conversion of onset atrial fibrillation (AF) to sinus rhythm in adults, and AGGRASTAT (tirofiban hydrochloride (HCl)), indicated for use in patients with acute coronary syndrome. Cardiome also commercializes ESMOCARD and ESMOCARD LYO (esmolol hydrochloride), a short-acting beta-blocker used to control heart rate in various cardiovascular indications, in select European markets. Cardiome has also licensed TREVYENT, a development-stage drug device combination product that is under development for pulmonary arterial hypertension, in certain regions outside the United States.

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