Zafgen (NASDAQ: ZFGN) is one of 296 public companies in the “Bio Therapeutic Drugs” industry, but how does it weigh in compared to its peers? We will compare Zafgen to related businesses based on the strength of its dividends, profitability, valuation, risk, earnings, analyst recommendations and institutional ownership.

Institutional and Insider Ownership

48.5% of Zafgen shares are held by institutional investors. Comparatively, 50.4% of shares of all “Bio Therapeutic Drugs” companies are held by institutional investors. 21.2% of Zafgen shares are held by company insiders. Comparatively, 16.4% of shares of all “Bio Therapeutic Drugs” companies are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Valuation & Earnings

This table compares Zafgen and its peers top-line revenue, earnings per share (EPS) and valuation.

Gross Revenue EBITDA Price/Earnings Ratio
Zafgen N/A -$50.51 million -1.88
Zafgen Competitors $263.26 million $68.25 million -6.44

Zafgen’s peers have higher revenue and earnings than Zafgen. Zafgen is trading at a higher price-to-earnings ratio than its peers, indicating that it is currently more expensive than other companies in its industry.

Analyst Ratings

This is a breakdown of recent ratings and target prices for Zafgen and its peers, as provided by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zafgen 0 1 1 0 2.50
Zafgen Competitors 766 3047 11235 227 2.72

Zafgen presently has a consensus target price of $9.00, indicating a potential upside of 152.81%. As a group, “Bio Therapeutic Drugs” companies have a potential upside of 35.75%. Given Zafgen’s higher probable upside, research analysts clearly believe Zafgen is more favorable than its peers.

Volatility and Risk

Zafgen has a beta of -1.36, indicating that its stock price is 236% less volatile than the S&P 500. Comparatively, Zafgen’s peers have a beta of 6.66, indicating that their average stock price is 566% more volatile than the S&P 500.


This table compares Zafgen and its peers’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Zafgen N/A -44.54% -40.97%
Zafgen Competitors -5,486.48% -451.59% -42.57%


Zafgen peers beat Zafgen on 7 of the 12 factors compared.

About Zafgen

Zafgen, Inc. is a biopharmaceutical company. The Company is focused on improving the health and well-being of patients affected by obesity and complex metabolic disorders. The Company’s lead product candidate, Beloranib, is a twice-weekly subcutaneous injection being developed for the treatment of multiple indications, including severe obesity in rare diseases, such as Prader-Willi syndrome (PWS) and hypothalamic injury-associated obesity (HIAO), including craniopharyngioma-associated obesity. Beloranib is in Phase III stage of development for PWS. It is also developing ZGN-839, a liver-targeted methionine aminopeptidase 2 (MetAP2) inhibitor, for the treatment of nonalcoholic steatohepatitis (NASH) and abdominal obesity, as well as other second-generation MetAP2 inhibitors for the treatment of severe obesity. It is also evaluating additional MetAP2 inhibitors beyond Beloranib as a development candidate for the treatment of severe obesity in the general population.

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