Adamas Pharmaceuticals (NASDAQ: ADMS) and Prosensa Holding NV (NASDAQ:RNA) are both small-cap medical companies, but which is the better business? We will contrast the two businesses based on the strength of their valuation, earnings, profitability, dividends, analyst recommendations, risk and institutional ownership.


This table compares Adamas Pharmaceuticals and Prosensa Holding NV’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Adamas Pharmaceuticals N/A -68.00% -53.83%
Prosensa Holding NV N/A -72.90% -57.94%

Institutional and Insider Ownership

70.6% of Adamas Pharmaceuticals shares are owned by institutional investors. 29.0% of Adamas Pharmaceuticals shares are owned by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.

Valuation and Earnings

This table compares Adamas Pharmaceuticals and Prosensa Holding NV’s revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio NetIncome Earnings Per Share Price/Earnings Ratio
Adamas Pharmaceuticals $570,000.00 1,150.59 -$60.05 million ($3.37) -8.54
Prosensa Holding NV N/A N/A N/A ($0.50) -37.30

Prosensa Holding NV has higher revenue, but lower earnings than Adamas Pharmaceuticals. Prosensa Holding NV is trading at a lower price-to-earnings ratio than Adamas Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

Analyst Ratings

This is a summary of recent ratings and recommmendations for Adamas Pharmaceuticals and Prosensa Holding NV, as provided by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Adamas Pharmaceuticals 0 0 7 0 3.00
Prosensa Holding NV 0 0 0 0 N/A

Adamas Pharmaceuticals presently has a consensus price target of $42.00, indicating a potential upside of 45.88%. Given Adamas Pharmaceuticals’ higher probable upside, analysts plainly believe Adamas Pharmaceuticals is more favorable than Prosensa Holding NV.


Adamas Pharmaceuticals beats Prosensa Holding NV on 7 of the 8 factors compared between the two stocks.

Adamas Pharmaceuticals Company Profile

Adamas Pharmaceuticals, Inc. is a pharmaceutical company. The Company is engaged in developing medicines to manage the daily lives of those affected by chronic neurologic disorders. It offers a platform based on an understanding of time dependent biologic effects of disease activity and drug response to achieve relief without tolerability issues. It has developed a portfolio of chrono-synchronous therapies to address chronic neurologic disorders. Its first product candidate is ADS-5102, a chrono-synchronous amantadine therapy, for the treatment of levodopa-induced dyskinesia (LID) in patients with Parkinson’s disease (PD). It has completed Phase II proof-of-concept study of ADS-5102 in these patients. Its Phase III clinical program included three placebo-controlled trials: EASED, EASE LID and EASE LID 3. Its second product candidate is ADS-4101, an extended-release version of single-agent compound for the treatment of epilepsy (partial onset seizures).

Prosensa Holding NV Company Profile

Prosensa Holding N.V., formerly Prosensa Holding B.V., is a biotechnology company engaged in the discovery and development of ribonucleic acid-modulating (RNA)-modulating, therapeutics for the treatment of genetic disorders. The Company’s primary focus is on rare neuromuscular and neurodegenerative disorders with a large unmet medical need, including Duchenne muscular dystrophy, myotonic dystrophy and Huntington’s disease. The Company’s clinical portfolio of RNA-based product candidates is focused on the treatment of Duchenne muscular dystrophy (DMD). The Company’s platform technology allows the development of RNA-modulating therapeutics that either interferes with splicing (exon skipping, exon inclusion, or splice mutation correction), remove mutant RNA, or block RNA expression, for different indications.

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