Signal Genetics (NASDAQ: MGEN) and BG Medicine (OTCMKTS:BGMD) are both small-cap medical companies, but which is the better business? We will contrast the two businesses based on the strength of their analyst recommendations, earnings, dividends, valuation, institutional ownership, profitability and risk.

Risk & Volatility

Signal Genetics has a beta of 1.92, suggesting that its stock price is 92% more volatile than the S&P 500. Comparatively, BG Medicine has a beta of 1.81, suggesting that its stock price is 81% more volatile than the S&P 500.

Earnings & Valuation

This table compares Signal Genetics and BG Medicine’s revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Signal Genetics $3.34 million 53.24 -$12.67 million $0.15 53.13
BG Medicine $1.57 million 0.29 -$5.30 million N/A N/A

BG Medicine has lower revenue, but higher earnings than Signal Genetics.


This table compares Signal Genetics and BG Medicine’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Signal Genetics -720.38% -80.31% -64.59%
BG Medicine N/A N/A N/A

Institutional and Insider Ownership

22.6% of Signal Genetics shares are owned by institutional investors. 44.4% of Signal Genetics shares are owned by company insiders. Comparatively, 6.5% of BG Medicine shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company is poised for long-term growth.

Analyst Ratings

This is a summary of current ratings for Signal Genetics and BG Medicine, as provided by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Signal Genetics 0 0 3 0 3.00
BG Medicine 0 0 0 0 N/A

Signal Genetics currently has a consensus price target of $23.00, indicating a potential upside of 188.58%. Given Signal Genetics’ higher probable upside, equities research analysts plainly believe Signal Genetics is more favorable than BG Medicine.


Signal Genetics beats BG Medicine on 7 of the 11 factors compared between the two stocks.

About Signal Genetics

Signal Genetics, Inc. is a commercial stage, molecular genetic diagnostic company. The Company is focused on providing diagnostic services that help physicians to make decisions concerning the care of cancer patients. The Company’s diagnostic service is the Myeloma Prognostic Risk Signature (MyPRS) test. The MyPRS test is a microarray-based gene expression profile (GEP), assay that measures the expression level of specific genes and groups of genes that are designed to predict an individual’s long-term clinical outcome/prognosis, giving a basis for personalized treatment options. The Company’s MyPRS test provides a whole-genomic expression profile of a patient’s multiple myeloma (MM). The Company offers MyPRS test in its laboratory located in Little Rock, Arkansas. The Company is licensed to sell its test in all 50 states.

About BG Medicine

BG Medicine, Inc. (BG Medicine) is a commercial-stage diagnostics company. The Company is engaged in commercializing diagnostic products that may be used to help guide the care and management of patients suffering from heart failure and related disorders. The Company’s BGM Galectin-3 Test is an in vitro diagnostic device that employs a manual micro-titer platform to measure galectin-3 levels in blood plasma or serum for use as an aid in assessing the prognosis of chronic heart failure in conjunction with clinical evaluation. The automated galectin-3 tests are being developed and commercialized by its diagnostic instrument manufacturing partners and will be performed on its partners’ automated platforms. The Company’s CardioSCORE test is a multi-analyte biomarker-based blood test that was designed as an aid in the assessment of near-term risk for atherothrombotic cardiovascular events, such as heart attack and ischemic stroke.

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