Cannabis Science (OTCMKTS: CBIS) and Signal Genetics (NASDAQ:MGEN) are both small-cap healthcare companies, but which is the better business? We will compare the two companies based on the strength of their risk, institutional ownership, valuation, dividends, analyst recommendations, profitability and earnings.

Analyst Recommendations

This is a breakdown of current recommendations and price targets for Cannabis Science and Signal Genetics, as reported by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Cannabis Science 0 0 0 0 N/A
Signal Genetics 0 0 3 0 3.00

Signal Genetics has a consensus price target of $24.00, suggesting a potential upside of 199.63%. Given Signal Genetics’ higher probable upside, analysts clearly believe Signal Genetics is more favorable than Cannabis Science.

Risk and Volatility

Cannabis Science has a beta of -4.04, suggesting that its share price is 504% less volatile than the S&P 500. Comparatively, Signal Genetics has a beta of 1.92, suggesting that its share price is 92% more volatile than the S&P 500.

Earnings and Valuation

This table compares Cannabis Science and Signal Genetics’ revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Cannabis Science N/A N/A N/A N/A N/A
Signal Genetics $3.34 million 53.50 -$12.67 million $0.15 53.40

Cannabis Science has higher earnings, but lower revenue than Signal Genetics.


This table compares Cannabis Science and Signal Genetics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Cannabis Science -953,196.00% N/A -380.46%
Signal Genetics -720.38% -80.31% -64.59%

Institutional & Insider Ownership

22.6% of Signal Genetics shares are held by institutional investors. 44.4% of Signal Genetics shares are held by company insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.


Signal Genetics beats Cannabis Science on 8 of the 9 factors compared between the two stocks.

About Cannabis Science

Cannabis Science, Inc. is engaged in medical marijuana research and development. The Company works on phytocannabinoid science targeting critical illnesses, and adheres to scientific methodologies to develop, produce and commercialize phytocannabinoid-based pharmaceutical products. The Company is involved in the creation of cannabis-based medicines, both with and without psychoactive properties, to treat disease and the symptoms of disease, as well as for general health maintenance. The Company focuses on the development of governmentally approved pharmaceuticals, including CS-TATI1, CS-S/BCC-1 and neurological therapy under study or development. The Company’s subsidiaries include Cannabis Science BV and Cannabis Science International Holding BV.

About Signal Genetics

Signal Genetics, Inc. is a commercial stage, molecular genetic diagnostic company. The Company is focused on providing diagnostic services that help physicians to make decisions concerning the care of cancer patients. The Company’s diagnostic service is the Myeloma Prognostic Risk Signature (MyPRS) test. The MyPRS test is a microarray-based gene expression profile (GEP), assay that measures the expression level of specific genes and groups of genes that are designed to predict an individual’s long-term clinical outcome/prognosis, giving a basis for personalized treatment options. The Company’s MyPRS test provides a whole-genomic expression profile of a patient’s multiple myeloma (MM). The Company offers MyPRS test in its laboratory located in Little Rock, Arkansas. The Company is licensed to sell its test in all 50 states.

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