Regulus Therapeutics (NASDAQ: RGLS) and Galectin Therapeutics (NASDAQ:GALT) are both small-cap medical companies, but which is the better stock? We will compare the two companies based on the strength of their earnings, risk, analyst recommendations, profitability, institutional ownership, dividends and valuation.

Risk & Volatility

Regulus Therapeutics has a beta of 1.53, meaning that its share price is 53% more volatile than the S&P 500. Comparatively, Galectin Therapeutics has a beta of 2.56, meaning that its share price is 156% more volatile than the S&P 500.


This table compares Regulus Therapeutics and Galectin Therapeutics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Regulus Therapeutics -107,606.96% -189.71% -92.92%
Galectin Therapeutics N/A -1,747.01% -160.00%

Analyst Ratings

This is a breakdown of recent ratings and price targets for Regulus Therapeutics and Galectin Therapeutics, as provided by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Regulus Therapeutics 0 5 1 0 2.17
Galectin Therapeutics 0 1 3 0 2.75

Regulus Therapeutics presently has a consensus target price of $2.88, indicating a potential upside of 217.43%. Galectin Therapeutics has a consensus target price of $5.00, indicating a potential upside of 105.76%. Given Regulus Therapeutics’ higher probable upside, equities research analysts plainly believe Regulus Therapeutics is more favorable than Galectin Therapeutics.

Earnings & Valuation

This table compares Regulus Therapeutics and Galectin Therapeutics’ gross revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Regulus Therapeutics $1.19 million 79.12 -$81.83 million ($1.35) -0.67
Galectin Therapeutics N/A N/A -$21.43 million ($0.55) -4.42

Galectin Therapeutics has lower revenue, but higher earnings than Regulus Therapeutics. Galectin Therapeutics is trading at a lower price-to-earnings ratio than Regulus Therapeutics, indicating that it is currently the more affordable of the two stocks.

Institutional and Insider Ownership

59.4% of Regulus Therapeutics shares are held by institutional investors. Comparatively, 11.1% of Galectin Therapeutics shares are held by institutional investors. 4.8% of Regulus Therapeutics shares are held by company insiders. Comparatively, 38.8% of Galectin Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company will outperform the market over the long term.


Galectin Therapeutics beats Regulus Therapeutics on 7 of the 12 factors compared between the two stocks.

About Regulus Therapeutics

Regulus Therapeutics Inc. is a biopharmaceutical company focused on discovering and developing drugs that target microRNAs to treat a range of diseases. The Company uses its microRNA product platform to develop chemically modified, single-stranded oligonucleotides that the Company calls anti-miRs to modulate microRNAs and return diseased cells to their healthy state. The Company’s Regulus microMarkers division is focused on identifying microRNAs as biomarkers of human disease. It has a research collaboration with Biogen focused on the discovery of microRNAs as biomarkers for multiple sclerosis and has completed research for another pharmaceutical company to explore microRNAs as biomarkers for specific patient populations. The Company is developing RG-101, an N-Acetylgalactosamine (GalNAc)-conjugated anti-miR targeting miR-122; RG-012, an anti-miR targeting microRNA-21 for the treatment of Alport syndrome, and RG-125, a GalNAc-conjugated anti-miR targeting microRNA-103/107.

About Galectin Therapeutics

Galectin Therapeutics Inc. is a clinical-stage biopharmaceutical company engaged in drug research and development to create therapies for fibrotic disease and cancer. The Company’s drug candidates are based on its method of targeting galectin proteins, which are mediators of biologic and pathologic functions. It uses naturally occurring, readily-available plant materials as starting material in manufacturing processes to create complex carbohydrates with specific molecular weights and other pharmaceutical properties. The Company has two product candidates, GR-MD-02 and GM-CT-01. The Company’s galectin-3 inhibitor is GR-MD-02. The Company is focusing on development of GR-MD-02 intended to be used in the treatment of liver fibrosis associated with fatty liver disease (NASH), moderate to severe plaque psoriasis and in cancer therapy in combination with immune-system modifying agent(s). GM-CT-01 is a compound that continues to be explored in preclinical studies.

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