Alexza Pharmaceuticals (OTCMKTS: ALXA) and Endo International (NASDAQ:ENDP) are both healthcare companies, but which is the better investment? We will contrast the two businesses based on the strength of their earnings, valuation, dividends, profitability, risk, analyst recommendations and institutional ownership.

Institutional and Insider Ownership

93.2% of Endo International shares are held by institutional investors. 0.5% of Endo International shares are held by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.

Profitability

This table compares Alexza Pharmaceuticals and Endo International’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Alexza Pharmaceuticals -466.94% N/A -106.54%
Endo International -126.97% 66.98% 8.38%

Valuation & Earnings

This table compares Alexza Pharmaceuticals and Endo International’s gross revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Alexza Pharmaceuticals N/A N/A N/A ($1.22) N/A
Endo International $4.01 billion 0.43 -$3.35 billion ($22.45) -0.34

Alexza Pharmaceuticals has higher earnings, but lower revenue than Endo International. Endo International is trading at a lower price-to-earnings ratio than Alexza Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

Analyst Ratings

This is a summary of recent ratings and target prices for Alexza Pharmaceuticals and Endo International, as reported by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Alexza Pharmaceuticals 0 0 0 0 N/A
Endo International 1 15 4 0 2.15

Endo International has a consensus price target of $11.59, indicating a potential upside of 50.18%.

Summary

Endo International beats Alexza Pharmaceuticals on 7 of the 8 factors compared between the two stocks.

Alexza Pharmaceuticals Company Profile

Alexza Pharmaceuticals, Inc. is a pharmaceutical company focused on the research, development and commercialization of products for the acute treatment of central nervous system conditions. The Company’s product candidates are based on the Staccato system technology. Its product candidates in development include AZ-002, which contains alprazolam as an active pharmaceutical ingredient (API) is developed for the management of patients with acute repetitive seizures, and AZ-007, which contains zaleplon as API is developed for the treatment of insomnia in patients who have difficulty falling asleep, including those patients with middle of the night awakening having difficulty falling back asleep. Its product also includes ADASUVE, which contains loxapine as API is developed for the treatment of agitation associated with schizophrenia or bipolar disorder. It has initiated a Phase IIa proof-of-concept study for AZ-002 in patients with epilepsy and has completed Phase I testing for AZ-007.

Endo International Company Profile

Endo International PLC, formerly Endo Health Solutions Inc. is a specialty healthcare solutions company focused on branded and generic pharmaceuticals, devices and services. The Company has a portfolio of branded pharmaceuticals that includes brands, such as Lidoderm, Opana ER, Voltaren Gel, Percocet, Frova, Supprelin LA, Vantas, Valstar and Fortesta Gel. The Company operates in three segments: Endo Pharmaceuticals, Qualitest and AMS. In June 2014, the Company’s subsidiary, Endo Pharmaceuticals sold its pharmaceutical drug discovery platform to AsanaBioSciences, LLC. In June 2014, Asana BioSciences, LLC, an independent member of Amneal Alliance of Companies, acquired early-stage branded pharmaceutical discovery platform of Endo Pharmaceuticals, a subsidiary of Endo International plc. In June 2014, Trendlines Group acquired intellectual property developed within the framework of an R&D agreement with the Company. In July 2014, it acquired Grupo Farmaceutico Somar.

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