Ambit Biosciences (NASDAQ: AMBI) and Onconova Therapeutics (NASDAQ:ONTX) are both healthcare companies, but which is the better stock? We will compare the two businesses based on the strength of their analyst recommendations, valuation, institutional ownership, risk, profitability, dividends and earnings.

Valuation and Earnings

This table compares Ambit Biosciences and Onconova Therapeutics’ top-line revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Ambit Biosciences N/A N/A N/A ($1.42) N/A
Onconova Therapeutics $5.55 million 2.70 -$19.66 million ($2.77) -0.50

Ambit Biosciences has higher earnings, but lower revenue than Onconova Therapeutics. Onconova Therapeutics is trading at a lower price-to-earnings ratio than Ambit Biosciences, indicating that it is currently the more affordable of the two stocks.


This table compares Ambit Biosciences and Onconova Therapeutics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Ambit Biosciences N/A N/A N/A
Onconova Therapeutics -2,855.94% -558.97% -144.30%

Insider and Institutional Ownership

25.4% of Onconova Therapeutics shares are held by institutional investors. 27.3% of Onconova Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Analyst Recommendations

This is a summary of recent ratings and recommmendations for Ambit Biosciences and Onconova Therapeutics, as provided by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Ambit Biosciences 0 0 0 0 N/A
Onconova Therapeutics 0 0 4 0 3.00

Onconova Therapeutics has a consensus target price of $7.33, suggesting a potential upside of 427.58%.

Ambit Biosciences Company Profile

Ambit Biosciences Corporation is a biopharmaceutical company. The Company focused on the discovery, development and commercialization of drugs to treat unmet medical needs in oncology, autoimmune and inflammatory diseases by inhibiting kinases that are important drivers for those diseases. The Company’s lead drug candidate, quizartinib, is in Phase IIb clinical development in patients with relapsed/refractory acute myeloid leukemia (AML). The Company’s second drug candidate in clinical development, AC410, is a potent, selective, orally-administered, small molecule inhibitor of Janus kinase 2 (JAK2) that has potential utility for the treatment of autoimmune and inflammatory diseases. The Company’s third program consists of two selective small molecule compounds, AC708 and AC855, which inhibit the colony-stimulating factor-1 receptor (CSF1R), a receptor tyrosine kinase.

Onconova Therapeutics Company Profile

Onconova Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company operates through the identification and development of oncology therapeutics segment. It is focused on discovering and developing small molecule drug candidates to treat cancer. The Company has created a targeted anti-cancer agents designed to work against specific cellular pathways that are important to cancer cells. It has over three clinical-stage product candidates and various preclinical programs that target kinases, cellular metabolism or cell division in preclinical development. The Company’s lead product candidate, rigosertib, is being tested in both intravenous (IV) and oral formulations as a single agent, and the oral formulation is also being tested in combination with azacitidine, in clinical trials for patients with myelodysplastic syndromes (MDS), and related cancers. Its other product candidates include Briciclib and Recilisib.

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