Analyzing Denali Therapeutics (DNLI) & Its Rivals

Denali Therapeutics (NASDAQ: DNLI) is one of 290 public companies in the “Bio Therapeutic Drugs” industry, but how does it weigh in compared to its competitors? We will compare Denali Therapeutics to similar companies based on the strength of its analyst recommendations, institutional ownership, dividends, earnings, valuation, profitability and risk.

Analyst Recommendations

This is a summary of recent ratings and price targets for Denali Therapeutics and its competitors, as reported by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Denali Therapeutics 0 1 3 0 2.75
Denali Therapeutics Competitors 1148 3465 11991 242 2.67

Denali Therapeutics presently has a consensus price target of $24.00, suggesting a potential upside of 21.46%. As a group, “Bio Therapeutic Drugs” companies have a potential upside of 37.24%. Given Denali Therapeutics’ competitors higher probable upside, analysts clearly believe Denali Therapeutics has less favorable growth aspects than its competitors.

Earnings and Valuation

This table compares Denali Therapeutics and its competitors top-line revenue, earnings per share and valuation.

Gross Revenue Net Income Price/Earnings Ratio
Denali Therapeutics N/A N/A -19.18
Denali Therapeutics Competitors $290.27 million $35.99 million 57.74

Denali Therapeutics’ competitors have higher revenue and earnings than Denali Therapeutics. Denali Therapeutics is trading at a lower price-to-earnings ratio than its competitors, indicating that it is currently more affordable than other companies in its industry.


This table compares Denali Therapeutics and its competitors’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Denali Therapeutics N/A N/A N/A
Denali Therapeutics Competitors -5,399.58% -161.85% -35.69%

Insider & Institutional Ownership

49.4% of shares of all “Bio Therapeutic Drugs” companies are held by institutional investors. 17.5% of shares of all “Bio Therapeutic Drugs” companies are held by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.


Denali Therapeutics competitors beat Denali Therapeutics on 6 of the 11 factors compared.

Denali Therapeutics Company Profile

Denali Therapeutics Inc. is a biotechnology company. The Company is focused on the discovery and development of therapies for patients with neurodegenerative disease, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS) and others. The Company is developing a diversified portfolio of therapeutics, based on scientific insights into the genetic causes and biological processes underlying neurodegenerative disease. The Company has selected approximately four specific pathways that are implicated as triggers or effectors of neurodegeneration, including degenogenes (genes that cause neurodegenerative disease when mutated), defective intracellular trafficking, glial dysfunction and axon degeneration. The Company’s development programs include Lysosomal Function Pathway, Glial Biology Pathway, and Cellular Homeostasis Pathway. Its product pipeline includes drug candidates such as DNL201, DNL 151, ATV:aSyn, ETV:IDS, DNL747, and ATV:TREM2.

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