Critical Review: Proteostasis Therapeutics (PTI) & Intec Pharma (NTEC)

Proteostasis Therapeutics (NASDAQ: PTI) and Intec Pharma (NASDAQ:NTEC) are both small-cap healthcare companies, but which is the better business? We will contrast the two businesses based on the strength of their analyst recommendations, profitability, institutional ownership, risk, dividends, valuation and earnings.

Insider and Institutional Ownership

51.8% of Proteostasis Therapeutics shares are held by institutional investors. Comparatively, 40.2% of Intec Pharma shares are held by institutional investors. 17.4% of Proteostasis Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company will outperform the market over the long term.

Analyst Ratings

This is a summary of recent ratings and recommmendations for Proteostasis Therapeutics and Intec Pharma, as provided by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Proteostasis Therapeutics 0 0 3 0 3.00
Intec Pharma 0 0 4 0 3.00

Proteostasis Therapeutics currently has a consensus price target of $16.00, indicating a potential upside of 284.62%. Intec Pharma has a consensus price target of $12.00, indicating a potential upside of 71.43%. Given Proteostasis Therapeutics’ higher probable upside, analysts clearly believe Proteostasis Therapeutics is more favorable than Intec Pharma.


This table compares Proteostasis Therapeutics and Intec Pharma’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Proteostasis Therapeutics -712.49% -93.15% -76.61%
Intec Pharma N/A N/A N/A

Valuation & Earnings

This table compares Proteostasis Therapeutics and Intec Pharma’s revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Proteostasis Therapeutics $8.38 million 16.44 -$37.23 million ($2.21) -1.88
Intec Pharma N/A N/A -$13.36 million N/A N/A

Intec Pharma has lower revenue, but higher earnings than Proteostasis Therapeutics.


Intec Pharma beats Proteostasis Therapeutics on 5 of the 9 factors compared between the two stocks.

Proteostasis Therapeutics Company Profile

Proteostasis Therapeutics, Inc. is a biopharmaceutical company. The Company is engaged in discovery and development of therapeutics that treat diseases caused by an imbalance in the proteostasis network, a set of pathways that control protein biosynthesis, folding, trafficking and clearance. It has developed the Disease Relevant Translation (DRT) technology platform, a drug screening approach for identifying highly translatable therapeutics based on predictive and functionally pertinent phenotypic assays and disease relevant models. Using this platform, it has identified a new class of small molecules, amplifiers that modulate proteins in the proteostasis network. It is developing and intend to commercialize its lead amplifier of CFTR protein, PTI-428, to improve CFTR protein function. It also focuses on developing PTI-NC-733, PTI-130, Usp14 program and unfolded protein response (UPR) program. PTI-130 is a small molecule amplifier.

Intec Pharma Company Profile

Intec Pharma Ltd is an Israel-based drug development company. It is a development stage biopharmaceutical company that develops formulations of drugs using its proprietary gastric retention technology, the Accordion Pill. The Accordion Pill, a novel gastro-retentive delivery system, improves the pharmacokinetics and pharmacodynamics of various drugs. The Company is focusing on the clinical development program for the Phase III clinical study of the Accordion Pill Carbidopa Levodopa (AP-CDLD), for the treatment of advanced stages Parkinson’s disease patients. Its pipeline also comprises The Accordion Pill-Zaleplon, a drug for sleep onset, which is in Phase II clinical program. Furthermore under research is Accordion Pill-Undisclosed Drug for the prevention and treatment of small bowel non-steroidal anti-inflammatory drug (NSAID) induced ulcers.

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