Head to Head Contrast: ChemoCentryx (NASDAQ:CCXI) vs. Arbutus Biopharma (NASDAQ:ABUS)

ChemoCentryx (NASDAQ:CCXI) and Arbutus Biopharma (NASDAQ:ABUS) are both small-cap medical companies, but which is the superior investment? We will compare the two companies based on the strength of their profitability, dividends, risk, institutional ownership, valuation, analyst recommendations and earnings.

Insider & Institutional Ownership

64.3% of ChemoCentryx shares are owned by institutional investors. Comparatively, 36.5% of Arbutus Biopharma shares are owned by institutional investors. 12.2% of ChemoCentryx shares are owned by insiders. Comparatively, 9.6% of Arbutus Biopharma shares are owned by insiders. Strong institutional ownership is an indication that endowments, large money managers and hedge funds believe a company is poised for long-term growth.


This table compares ChemoCentryx and Arbutus Biopharma’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
ChemoCentryx -144.27% -103.61% -23.08%
Arbutus Biopharma -1,948.40% -125.64% -36.05%

Earnings & Valuation

This table compares ChemoCentryx and Arbutus Biopharma’s top-line revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
ChemoCentryx $42.88 million 10.14 -$37.97 million ($0.76) -9.86
Arbutus Biopharma $5.90 million 16.48 -$57.06 million ($1.02) -1.68

ChemoCentryx has higher revenue and earnings than Arbutus Biopharma. ChemoCentryx is trading at a lower price-to-earnings ratio than Arbutus Biopharma, indicating that it is currently the more affordable of the two stocks.

Analyst Ratings

This is a breakdown of recent recommendations and price targets for ChemoCentryx and Arbutus Biopharma, as provided by MarketBeat.com.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
ChemoCentryx 0 0 6 1 3.14
Arbutus Biopharma 0 3 2 0 2.40

ChemoCentryx presently has a consensus target price of $18.33, indicating a potential upside of 143.79%. Arbutus Biopharma has a consensus target price of $6.33, indicating a potential upside of 263.98%. Given Arbutus Biopharma’s higher probable upside, analysts clearly believe Arbutus Biopharma is more favorable than ChemoCentryx.

Volatility & Risk

ChemoCentryx has a beta of 1.19, indicating that its share price is 19% more volatile than the S&P 500. Comparatively, Arbutus Biopharma has a beta of 1.65, indicating that its share price is 65% more volatile than the S&P 500.


ChemoCentryx beats Arbutus Biopharma on 11 of the 15 factors compared between the two stocks.

About ChemoCentryx

ChemoCentryx, Inc., a clinical-stage biopharmaceutical company, develops new medications for inflammatory and autoimmune diseases, and cancer in the United States. The company targets the chemokine and chemoattractant systems to discover, develop, and commercialize orally-administered therapies. Its lead drug candidate is Avacopan, an orally-administered complement inhibitor of the complement C5a receptor (C5aR), is in Phase III development for the treatment of anti-neutrophil cytoplasmic auto-antibody-associated vasculitis. The company is also developing Avacopan for the treatment of patients with complement 3 glomerulopathy and hidradenitis suppurativa. In addition, the company is developing CCX140, an inhibitor of the chemokine receptor known as CCR2, which has completed a Phase II clinical trial in diabetic nephropathy and is being developed for patients with focal segmental glomerulosclerosis. Further, it has early stage drug candidates that target chemoattractant receptors in other inflammatory and autoimmune diseases, and in cancer. The company was founded in 1997 and is headquartered in Mountain View, California.

About Arbutus Biopharma

Arbutus Biopharma Corporation, a biopharmaceutical company, engages in the discovery, development, and commercialization of a cure for patients suffering from chronic Hepatitis B virus (HBV) infection in Canada and the United States. Its HBV product pipeline consists of AB-506, a capsid inhibitor that has shown improved potency and pharmacokinetics over its first generation capsid inhibitor; and AB-423, which is in pre-clinical studies. The company also develops RNAi drugs, which utilize the RNA interference pathway, allows for a novel approach to treating disease. Its RNAi HBV candidates are designed to reduce hepatitis B surface antigen expression in patients chronically infected with HBV. The company develops AB-729, a second generation RNAi therapeutic targeted to hepatocytes; HBV RNA destabilizer AB-452, an orally administered agent, in pre-clinical studies in destabilizing HBV RNA, which leads to RNA degradation and to reduction in HBsAg levels. In addition, it engages conducting a Phase 1a/1b clinical trial and several pre-clinical and investigational new drug-enabling studies to evaluate proprietary HBV therapeutic agents, together with SOC therapies, and in combination with each other. The company has strategic alliance, licensing, and research collaboration agreements with Marqibo; Gritstone Oncology, Inc.; Acuitas Therapeutics Inc.; Alexion Pharmaceuticals Inc.; Monsanto Company; Marina Biotech, Inc.; and Arcturus Therapeutics, Inc. The company was formerly known as Tekmira Pharmaceuticals Corporation and changed its name to Arbutus Biopharma Corporation in July 2015. Arbutus Biopharma Corporation is headquartered in Burnaby, Canada.

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