Seer, Inc. (NASDAQ:SEER) Short Interest Up 126.6% in February

Seer, Inc. (NASDAQ:SEER) was the target of a significant increase in short interest during the month of February. As of February 13th, there was short interest totaling 634,111 shares, an increase of 126.6% from the January 29th total of 279,780 shares. Based on an average daily trading volume, of 352,140 shares, the short-interest ratio is currently 1.8 days. Currently, 1.3% of the shares of the company are short sold. Currently, 1.3% of the shares of the company are short sold. Based on an average daily trading volume, of 352,140 shares, the short-interest ratio is currently 1.8 days.

Analysts Set New Price Targets

A number of brokerages have recently issued reports on SEER. Wall Street Zen raised shares of Seer to a “hold” rating in a research report on Saturday, December 13th. Weiss Ratings reiterated a “sell (d-)” rating on shares of Seer in a research report on Thursday, January 22nd. One investment analyst has rated the stock with a Sell rating, According to data from MarketBeat, the company currently has an average rating of “Sell”.

Institutional Investors Weigh In On Seer

Several large investors have recently added to or reduced their stakes in SEER. Corient Private Wealth LLC purchased a new stake in Seer during the fourth quarter valued at approximately $116,000. Quadrature Capital Ltd purchased a new stake in Seer during the 4th quarter valued at $101,000. Barclays PLC lifted its position in Seer by 685.0% in the fourth quarter. Barclays PLC now owns 60,717 shares of the company’s stock worth $111,000 after buying an additional 52,982 shares during the last quarter. Marshall Wace LLP bought a new position in Seer during the fourth quarter valued at $85,000. Finally, Dimensional Fund Advisors LP increased its position in Seer by 2.8% during the fourth quarter. Dimensional Fund Advisors LP now owns 235,485 shares of the company’s stock valued at $431,000 after acquiring an additional 6,304 shares during the last quarter. 75.20% of the stock is owned by institutional investors.

Seer Stock Performance

SEER opened at $2.08 on Friday. Seer has a fifty-two week low of $1.62 and a fifty-two week high of $2.41. The company has a fifty day moving average of $1.90 and a 200 day moving average of $2.02. The stock has a market capitalization of $116.04 million, a price-to-earnings ratio of -1.53 and a beta of 1.63.

Seer (NASDAQ:SEER) last announced its quarterly earnings results on Thursday, February 26th. The company reported ($0.29) EPS for the quarter, beating analysts’ consensus estimates of ($0.32) by $0.03. The company had revenue of $4.20 million during the quarter, compared to analyst estimates of $4.60 million. Seer had a negative return on equity of 25.88% and a negative net margin of 484.51%. On average, equities research analysts forecast that Seer will post -1.42 earnings per share for the current year.

Key Stories Impacting Seer

Here are the key news stories impacting Seer this week:

• Positive Sentiment: Q4 EPS beat — Seer reported ($0.29) EPS vs. consensus ($0.32), and Q4 gross margin remained healthy (≈52%), showing operational progress despite losses. Seer Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Full Year 2026 Outlook
• Positive Sentiment: Installed base and cash position are strong — Seer grew its Proteograph installed base to 82 instruments (67% YoY) and ended 2025 with ≈$240.6M in cash/investments, giving runway to execute. Seer, Inc. Reports Fourth Quarter and Full Year 2025 Financial Results with Revenue Growth and Expanded Instrument Base
• Positive Sentiment: Board actions support shareholder value — Seer’s board approved a limited buyback program and adopted an NOL preservation plan to protect ≈$262M of tax assets, which can preserve future tax offsets. Seer outlines $16M–$18M 2026 revenue target as product innovation accelerates and new buyback approved Seer Adopts Limited Duration Tax Benefit Preservation Plan
• Neutral Sentiment: Full earnings materials and call transcript are available for review — useful for investors wanting color on kit pull‑through, instrument sales cadence, and pipeline. Seer (SEER) Q4 2025 Earnings Call Transcript
• Negative Sentiment: 2026 guidance materially below consensus — Seer guided to $16M–$18M revenue for 2026 (midpoint ≈$17M) versus analyst consensus near $22.1M, signaling modest growth and raising near‑term expectations risk. Seer Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Full Year 2026 Outlook
• Negative Sentiment: Large ongoing losses and revenue shortfall — FY‑2025 net loss was $73.6M and Q4 revenue of $4.2M missed analyst revenue expectations, keeping profitability distant and relying on continued cash reserves. Seer Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Full Year 2026 Outlook
• Negative Sentiment: Short interest rose sharply in February (≈126% increase), which may add volatility and reflect bearish positioning. (Short interest data reported Feb. 25)

Seer Company Profile

Seer, Inc is a life sciences company focused on pioneering next-generation proteomics, the large-scale study of proteins and their functions in complex biological systems. By leveraging proprietary nanoparticle-based technology, Seer’s platform enables high-throughput, unbiased protein analysis from biological samples, addressing a critical bottleneck in drug discovery, biomarker research and precision medicine.

The company’s flagship Proteograph Product Suite combines engineered nanoparticle assays with advanced mass spectrometry and bioinformatics pipelines to deliver deep proteomic coverage in a scalable workflow.